ingest: MS myelin glucose signaling article (2026-05-04)

Brain glucose levels regulate OPC fate: high glucose → proliferation,
low glucose → maturation. Acetyl-CoA from glucose drives histone
acetylation for OPC division; ketone bodies substitute for myelin
synthesis. Ketogenic diet rescues myelin in ACLY-deficient mice.

Connects to: N-Dimensional Gene Hypothesis, PIST polymorphic shifter,
topological state machine, FAMM delay lines, waveprobe manifolds

4-Infrastructure/shim/ingest_ms_myelin_article.py

@@ -0,0 +1,91 @@
+#!/usr/bin/env python3
+"""Ingest MS myelin glucose signaling article into Research Stack database."""
+
+import json, time, hashlib
+from pathlib import Path
+
+RESEARCH_STACK = Path("/home/allaun/Documents/Research Stack")
+
+ARTICLE = {
+    "id": "ms-myelin-glucose-2026-05-04",
+    "source": "https://multiplesclerosisnewstoday.com/news-posts/2026/05/04/brain-sugar-levels-act-signal-myelin-growth-study-finds/",
+    "title": "Brain sugar levels act as signal for myelin growth, study finds",
+    "date": "2026-05-04",
+    "publication": "Multiple Sclerosis News Today",
+    "summary": "Glucose levels in the brain regulate oligodendrocyte progenitor cell (OPC) fate — high glucose drives OPC proliferation via histone acetylation, low glucose triggers maturation into myelin-producing oligodendrocytes. Acetyl-CoA from glucose is required for OPC division; mature oligodendrocytes can source acetyl-CoA from ketone bodies for myelin synthesis. ACLY enzyme knockout reduces early myelin but ketogenic diet rescues it.",
+    "key_findings": [
+        "OPC activity correlates with local brain glucose levels",
+        "High glucose → acetyl-CoA → histone acetylation → OPC proliferation",
+        "Low glucose → OPC maturation into myelin-producing oligodendrocytes",
+        "ACLY enzyme required for glucose-to-acetyl-CoA conversion in OPCs",
+        "Mature oligodendrocytes use ketone bodies as alternative acetyl-CoA source",
+        "Ketogenic diet rescues myelin production in ACLY-deficient mice",
+        "Same cell lineage interprets different metabolic signals at distinct stages"
+    ],
+    "relevance_to_research_stack": {
+        "topics": [
+            "metabolic_epigenetic_switch",
+            "myelin_repair_mechanism",
+            "glucose_signaling_pathway",
+            "oligodendrocyte_differentiation",
+            "ketogenic_metabolic_intervention",
+            "histone_acetylation_gene_regulation"
+        ],
+        "connections": [
+            "N-Dimensional Gene Hypothesis: glucose gradient as spatial morphogen signal",
+            "PIST biological polymorphic shifter: metabolic state → cell fate switch",
+            "Topological state machine: glucose level as continuous state variable",
+            "FAMM delay lines: metabolic latency in cell fate decisions",
+            "Waveprobe manifolds: glucose gradient as scalar field on brain manifold"
+        ]
+    },
+    "metadata": {
+        "ingested_at": time.time(),
+        "content_hash": hashlib.sha256(
+            "glucose myelin OPC oligodendrocyte acetyl-CoA ACLY ketogenic histone acetylation".encode()
+        ).hexdigest()[:16],
+        "tags": ["neuroscience", "metabolism", "myelin", "multiple-sclerosis", "epigenetics", "glucose-signaling"]
+    }
+}
+
+
+def ingest():
+    # Save to germane research data
+    germane_dir = RESEARCH_STACK / "shared-data/data/germane/research"
+    germane_dir.mkdir(parents=True, exist_ok=True)
+    
+    out_path = germane_dir / "ms_myelin_glucose_signaling_2026-05-04.json"
+    with open(out_path, 'w') as f:
+        json.dump(ARTICLE, f, indent=2)
+    
+    print(f"✓ Ingested: {out_path}")
+    
+    # Append to research index
+    index_path = germane_dir / "research_ingestion_index.json"
+    index = []
+    if index_path.exists():
+        with open(index_path) as f:
+            index = json.load(f)
+    
+    index.append({
+        "id": ARTICLE["id"],
+        "title": ARTICLE["title"],
+        "date": ARTICLE["date"],
+        "source": ARTICLE["source"],
+        "ingested_at": ARTICLE["metadata"]["ingested_at"],
+        "tags": ARTICLE["metadata"]["tags"],
+    })
+    
+    with open(index_path, 'w') as f:
+        json.dump(index, f, indent=2)
+    
+    print(f"✓ Index updated: {index_path} ({len(index)} entries)")
+    
+    # Print connections
+    print(f"\nResearch Stack connections:")
+    for conn in ARTICLE["relevance_to_research_stack"]["connections"]:
+        print(f"  → {conn}")
+
+
+if __name__ == "__main__":
+    ingest()

6-Documentation/tiddlywiki-local/wiki/tiddlers/Hutter Critical Analysis.tid

@@ -29,3 +29,6 @@ counts, decompressor cost, and comparison baselines.
 * [[Hutter Prize Compression]]
 * [[Hutter Tensor Field Analysis DAG]]
 * [[Mass Number Sidecar Rule]]
+* [[Pathological Manifold Torus]]
+* [[Pathological Menger-Horn Composite]]
+* [[Pathological PIST Shells]]

6-Documentation/tiddlywiki-local/wiki/tiddlers/Hutter Prize Compression.tid

@@ -16,6 +16,9 @@ work.
 * [[PIST Shifters]]
 * [[Soliton N-Space Path]]
 * [[Compression and Soliton Mining]]
+* [[Pathological Manifold Torus]]
+* [[Pathological Menger-Horn Composite]]
+* [[Pathological PIST Shells]]
 
 !! Durable Sources
 

6-Documentation/tiddlywiki-local/wiki/tiddlers/PIST Shifters.tid

@@ -15,6 +15,9 @@ variants.
 * [[Hutter Prize Compression]]
 * [[Soliton N-Space Path]]
 * [[Compression and Soliton Mining]]
+* [[Pathological PIST Shells]]
+* [[Pathological Manifold Torus]]
+* [[Pathological Menger-Horn Composite]]
 
 !! Durable Source
 

6-Documentation/tiddlywiki-local/wiki/tiddlers/Pathological Manifold Torus.tid

@@ -0,0 +1,24 @@
+created: 20260506230000000
+modified: 20260506230000000
+tags: ResearchStack Compression Hutter CAD Geometry Torus
+title: Pathological Manifold Torus
+type: text/vnd.tiddlywiki
+
+! Pathological Manifold Torus
+
+3D slice of a hypertorus used as a PIST pathological manifold for Hutter Prize
+compression geometry. A 3D projection of the 4D structure, with points sampled
+via irrational φ-rotations (Φ, Φ², Φ³) and the psi angle encoded as color.
+
+The torus provides periodic boundary conditions for routing across the
+compression manifold — no endpoints, no zero-mass singularities.
+
+!! Links
+
+* [[Hutter Prize Compression]]
+* [[Pathological Menger-Horn Composite]]
+* [[Pathological PIST Shells]]
+
+!! Durable Source
+
+`../../3-Mathematical-Models/cad_models/hypertorus_slice.scad`

6-Documentation/tiddlywiki-local/wiki/tiddlers/Pathological Menger-Horn Composite.tid

@@ -0,0 +1,29 @@
+created: 20260506230000000
+modified: 20260506230000000
+tags: ResearchStack Compression Hutter CAD Geometry MengerSponge GabrielHorn
+title: Pathological Menger-Horn Composite
+type: text/vnd.tiddlywiki
+
+! Pathological Menger-Horn Composite
+
+Composite manifold: Menger sponge nodes mounted as structural attachment points
+along Gabriel's horn backbone (x-axis curve y = 1/x). PIST shell coordinates are
+nested inside each sponge node.
+
+The horn provides infinite surface area with finite volume — the byte container
+surface. The Menger sponge provides fractal addressing (Hausdorff dimension
+~2.7268) for routing between shells. Together they form one of three pathological
+manifolds for Hutter Prize compression-geometry folding.
+
+Composite structure is Torus-Menger-Horn, as referenced in
+[[04_Hutter_Prize_Equation.md|Hutter Prize Equation §Torus-Menger-Horn folding]].
+
+!! Links
+
+* [[Hutter Prize Compression]]
+* [[Pathological Manifold Torus]]
+* [[Pathological PIST Shells]]
+
+!! Durable Source
+
+`../../3-Mathematical-Models/cad_models/composite_manifold.scad`

6-Documentation/tiddlywiki-local/wiki/tiddlers/Pathological PIST Shells.tid

@@ -0,0 +1,30 @@
+created: 20260506230000000
+modified: 20260506230000000
+tags: ResearchStack Compression Hutter CAD Geometry PIST Shells
+title: Pathological PIST Shells
+type: text/vnd.tiddlywiki
+
+! Pathological PIST Shells
+
+Concentric polygonal rings representing PIST shell encoding. Each shell k is
+drawn as a regular (2k+1)-gon with radius proportional to k. Mirror involution
+axes are marked at the t = k symmetry points (red markers).
+
+Inner shells are dense with low curvature; outer shells are sparse with high
+curvature — this is the tension gradient used in compression. The mirror
+involution (k, t) → (k, 2k+1-t) preserves mass and is self-inverse, providing
+the geometric basis for resonance jumps and shell-preserving RG flow.
+
+One of three pathological manifold structures (Torus-Menger-Horn) for Hutter
+Prize compression folding.
+
+!! Links
+
+* [[PIST Shifters]]
+* [[Hutter Prize Compression]]
+* [[Pathological Manifold Torus]]
+* [[Pathological Menger-Horn Composite]]
+
+!! Durable Source
+
+`../../3-Mathematical-Models/cad_models/pist_shells.scad`