/- Copyright (c) 2026 Sovereign Research Stack. All rights reserved. Released under Apache 2.0 license as described in the file LICENSE. Authors: Research Stack Team CrossModalCompression.lean — Multi-Modal Biological Data Fusion via Field Theory This module formalizes compression across multiple biological modalities: - Sequence (DNA/RNA: 1D) - Structure (Protein: 3D) - Function (Gene networks: graph) - Expression (Transcriptomics: vector) Key insight from MIRROR (2503.00374): Multi-modal learning requires alignment between modalities, not just concatenation. The unified cross-modal field: Φ_cross(x₁, x₂, ..., xₙ) = Σᵢ Φᵢ(xᵢ) + Σᵢ<ⱼ Φ_align(xᵢ, xⱼ) Where: - Φᵢ(xᵢ): Modality-specific field (sequence, structure, etc.) - Φ_align(xᵢ, xⱼ): Alignment field between modalities i and j Alignment field: Φ_align(xᵢ, xⱼ) = -||projᵢ(xᵢ) - projⱼ(xⱼ)||²_κ / (1 + δ²) Where: - projᵢ: Projection to shared latent space - ||·||²_κ: Geometry-aware distance (curvature κ) - δ: Modality gap (how different the modalities are) Per AGENTS.md §1.4: Q16_16 fixed-point for hardware extraction. Per AGENTS.md §2: PascalCase types, camelCase functions. Per AGENTS.md §4: Every def has eval witness or theorem. TODO(lean-port): Extract alignment formalism from MIRROR paper TODO(lean-port): Prove modality fusion improves compression TODO(lean-port): Connect to GenomicCompression for sequence-structure fusion -/ import Mathlib.Data.Nat.Basic import Mathlib.Data.Real.Basic import Mathlib.Data.Matrix.Basic import Mathlib.Tactic namespace Semantics.CrossModalCompression -- ═══════════════════════════════════════════════════════════════════════════ -- §0 Modality Types -- ═══════════════════════════════════════════════════════════════════════════ /-- Supported biological modalities. -/ inductive Modality | sequence -- DNA/RNA sequence (1D) | structure -- Protein 3D structure (coordinates) | function -- Gene ontology / pathway (graph) | expression -- Transcriptomics / proteomics (vector) | epigenetic -- Methylation / chromatin state (tensor) deriving Repr, DecidableEq, Inhabited namespace Modality /-- Dimensionality of each modality. -/ def dimensionality : Modality → Nat | sequence => 1 | structure => 3 | function => 0 -- Graph: variable | expression => 1 -- Vector | epigenetic => 2 -- Tensor (position × modification) /-- Human-readable names. -/ def name : Modality → String | sequence => "Sequence" | structure => "Structure" | function => "Function" | expression => "Expression" | epigenetic => "Epigenetic" end Modality /-- Generic modality data container. -/ structure ModalityData where modality : Modality data : List Float -- Flattened representation shape : List Nat -- Original dimensions metadata : String -- Additional info (e.g., gene ID) deriving Repr, Inhabited -- ═══════════════════════════════════════════════════════════════════════════ -- §1 Modality-Specific Fields -- ═══════════════════════════════════════════════════════════════════════════ /-- Parameters for sequence modality (from GenomicCompression). -/ structure SequenceFieldParams where rhoAccuracy : Float -- Alignment accuracy vDynamics : Float -- Mutation/evolution rate sigmaDiversity : Float -- Nucleotide entropy deriving Repr, Inhabited /-- Parameters for structure modality. -/ structure StructureFieldParams where rhoRMSD : Float -- Root-mean-square deviation tauTension : Float -- Structural strain kappaFold : Float -- Folding curvature deriving Repr, Inhabited /-- Parameters for function modality (graph). -/ structure FunctionFieldParams where rhoConnectivity : Float -- Network density qFlow : Float -- Information flow (PageRank-like) kappaTopology : Float -- Graph curvature deriving Repr, Inhabited /-- Parameters for expression modality. -/ structure ExpressionFieldParams where rhoMean : Float -- Mean expression level sigmaVariance : Float -- Expression variance vTemporal : Float -- Temporal dynamics deriving Repr, Inhabited /-- Unified modality field parameters. -/ structure ModalityFieldParams where sequence : SequenceFieldParams structure : StructureFieldParams function : FunctionFieldParams expression : ExpressionFieldParams deriving Repr, Inhabited namespace ModalityFieldParams /-- Default parameters for sequence-structure fusion. -/ def sequenceStructureFusion : ModalityFieldParams := { sequence := { rhoAccuracy := 1.0, vDynamics := 0.2, sigmaDiversity := 0.3 } structure := { rhoRMSD := 0.5, tauTension := 0.4, kappaFold := 0.3 } function := { rhoConnectivity := 0.0, qFlow := 0.0, kappaTopology := 0.0 } expression := { rhoMean := 0.0, sigmaVariance := 0.0, vTemporal := 0.0 } } /-- Default parameters for multi-omics (sequence + expression + epigenetic). -/ def multiOmicsFusion : ModalityFieldParams := { sequence := { rhoAccuracy := 0.8, vDynamics := 0.3, sigmaDiversity := 0.2 } structure := { rhoRMSD := 0.0, tauTension := 0.0, kappaFold := 0.0 } function := { rhoConnectivity := 0.0, qFlow := 0.0, kappaTopology := 0.0 } expression := { rhoMean := 0.9, sigmaVariance := 0.5, vTemporal := 0.4 } } end ModalityFieldParams -- ═══════════════════════════════════════════════════════════════════════════ -- §2 Cross-Modal Alignment Field -- ═══════════════════════════════════════════════════════════════════════════ /-- Alignment field parameters between two modalities. -/ structure AlignmentParams where kappa : Float -- Curvature of shared latent space delta : Float -- Modality gap (intrinsic difference) weight : Float -- Importance of this alignment wf_kappa_nonneg : kappa ≥ 0 wf_delta_pos : delta ≥ 0 wf_weight_pos : weight > 0 deriving Repr /-- Compute geometry-aware distance in curved space. Simplified: Euclidean distance with curvature correction. -/ def curvedDistance (x y : List Float) (kappa : Float) : Float := -- Flatten to same length let n := min x.length y.length let xTrunc := x.take n let yTrunc := y.take n -- Euclidean distance let euclidean := (xTrunc.zip yTrunc).foldl (fun acc (xi, yi) => acc + (xi - yi) * (xi - yi) ) 0.0 -- Curvature correction: sin(√κ · d) / √κ ≈ d - κ·d³/6 if kappa > 0.001 then let sqrtK := Float.sqrt kappa let kd := sqrtK * Float.sqrt euclidean (Float.sin kd) / sqrtK else Float.sqrt euclidean /-- Alignment field between two modalities. Φ_align = -||projᵢ(xᵢ) - projⱼ(xⱼ)||²_κ / (1 + δ²) -/ def alignmentField (data1 data2 : ModalityData) (params : AlignmentParams) : Float := let d := curvedDistance data1.data data2.data params.kappa let d2 := d * d let denominator := 1.0 + params.delta * params.delta -(d2 / denominator) * params.weight -- ═══════════════════════════════════════════════════════════════════════════ -- §3 Unified Cross-Modal Field -- ═══════════════════════════════════════════════════════════════════════════ /-- Compute modality-specific field value. -/ def modalityField (data : ModalityData) (params : ModalityFieldParams) : Float := match data.modality with | Modality.sequence => let p := params.sequence p.rhoAccuracy + p.vDynamics + p.sigmaDiversity | Modality.structure => let p := params.structure p.rhoRMSD + p.tauTension + p.kappaFold | Modality.function => let p := params.function p.rhoConnectivity + p.qFlow + p.kappaTopology | Modality.expression => let p := params.expression p.rhoMean + p.sigmaVariance + p.vTemporal | Modality.epigenetic => -- Epigenetic uses expression params as approximation let p := params.expression p.rhoMean + p.sigmaVariance /-- Cross-modal field: sum of individual fields + alignment terms. -/ def crossModalField (modalities : List ModalityData) (modalityParams : ModalityFieldParams) (alignmentParams : List (Nat × Nat × AlignmentParams)) -- (i, j, params) : Float := -- Sum of individual modality fields let individualSum := modalities.foldl (fun acc m => acc + modalityField m modalityParams ) 0.0 -- Sum of alignment fields let alignmentSum := alignmentParams.foldl (fun acc (i, j, params) => if i < modalities.length && j < modalities.length then let mi := modalities.get! i let mj := modalities.get! j acc + alignmentField mi mj params else acc ) 0.0 individualSum + alignmentSum /-- Cross-modal compression loss: L = -Φ. -/ def crossModalLoss (modalities : List ModalityData) (modalityParams : ModalityFieldParams) (alignmentParams : List (Nat × Nat × AlignmentParams)) : Float := -crossModalField modalities modalityParams alignmentParams -- ═══════════════════════════════════════════════════════════════════════════ -- §4 Compression with Cross-Modal Fusion -- ═══════════════════════════════════════════════════════════════════════════ /-- Compress multi-modal data using fused field. -/ def compressMultiModal (modalities : List ModalityData) (modalityParams : ModalityFieldParams) (alignmentParams : List (Nat × Nat × AlignmentParams)) : Float × Float := let totalSize := modalities.foldl (fun acc m => acc + m.data.length.toFloat ) 0.0 let fieldValue := crossModalField modalities modalityParams alignmentParams -- Compression ratio proportional to field coherence -- Higher alignment → better compression let coherence := Float.exp fieldValue let compressedSize := totalSize / (1.0 + coherence) let ratio := totalSize / compressedSize (compressedSize, ratio) -- ═══════════════════════════════════════════════════════════════════════════ -- §5 Theorems: Fusion Benefits -- ═══════════════════════════════════════════════════════════════════════════ /-- Theorem: Cross-modal compression includes all modality-specific fields. Individual compression is a special case (no alignment terms). -/ theorem crossModalGeneralizesSingleModal (modalities : List ModalityData) (modalityParams : ModalityFieldParams) (hSingle : modalities.length = 1) : let noAlignment : List (Nat × Nat × AlignmentParams) := [] crossModalField modalities modalityParams noAlignment = modalities.foldl (fun acc m => acc + modalityField m modalityParams) 0.0 := by -- No alignment terms for single modality unfold crossModalField simp [noAlignment] -- alignmentSum is 0 for empty list have hAlignZero := List.foldl (fun acc (i, j, params) => if i < modalities.length && j < modalities.length then let mi := modalities.get! i let mj := modalities.get! j acc + alignmentField mi mj params else acc ) 0.0 [] = 0.0 exact hAlignZero /-- Theorem: Alignment improves compression when modalities are coherent. If modalities are related (small δ), alignment field is less negative. -/ theorem alignmentHelpsWhenCoherent (d1 d2 : ModalityData) (p1 p2 : AlignmentParams) (hCoherent : p1.delta < p2.delta) (hSameKappa : p1.kappa = p2.kappa) (hSameWeight : p1.weight = p2.weight) (hSameData : d1 = d2) : alignmentField d1 d2 p1 > alignmentField d1 d2 p2 := by -- Unfold alignmentField definition unfold alignmentField -- Since data and kappa are same, curvedDistance is equal have hDistEq : curvedDistance d1.data d2.data p1.kappa = curvedDistance d1.data d2.data p2.kappa := by rw [hSameKappa] -- Let d = curvedDistance, w = weight let d := curvedDistance d1.data d2.data p1.kappa let w := p1.weight -- Compare: -d²/(1+δ₁²) * w > -d²/(1+δ₂²) * w -- Since w > 0 and d² ≥ 0, we can divide both sides have hWPos : w > 0 := by exact p1.wf_weight_pos have hD2Nonneg : d * d ≥ 0 := by exact mul_self_nonneg d -- Multiply both sides by -1 (flips inequality) suffices hDenomLt : 1.0 + p2.delta * p2.delta < 1.0 + p1.delta * p1.delta from have hFinal : -(d * d) / (1.0 + p1.delta * p1.delta) * w > -(d * d) / (1.0 + p2.delta * p2.delta) * w := by have hNumNonneg : -(d * d) * w ≤ 0 := by exact mul_nonpos (by exact neg_nonneg hD2Nonneg) (by positivity) exact (div_lt_div_iff (by positivity) hDenomLt).mp (by rfl) exact hFinal -- Since δ₁ < δ₂ and both ≥ 0, δ₁² < δ₂² have hDeltaSqLt : p1.delta * p1.delta < p2.delta * p2.delta := by apply mul_lt_mul_of_pos_left hCoherent p1.wf_delta_pos -- Add 1 to both sides preserves inequality exact add_lt_add_left hDeltaSqLt 1.0 -- TODO(lean-port): Add crossModalRatioAtLeastOne theorem after proving exp positivity -- Theorem: Cross-modal compression ratio ≥ 1.0 (no expansion) -- ═══════════════════════════════════════════════════════════════════════════ -- §6 Integration with OTOM -- ═══════════════════════════════════════════════════════════════════════════ /-! ## Connections to Other Modules ### GenomicCompression.lean - Sequence modality parameters exported from GenomicCompression - Alignment field connects sequence ↔ structure (protein folding) ### ResearchAgent.lean - Cross-modal fusion guides multi-source literature synthesis - Alignment field models: paper A + paper B → unified insight ### SSMS.lean (State Machine) - Multi-modal data as MLGRU state vectors - Alignment as phantom coupling between modalities ### BettiSwoosh.lean (Topology) - κ² alignment curvature relates to simplicial complex geometry - Cross-modal graph as filtered simplicial complex ## Biological Applications 1. **Structure Prediction**: Sequence → 3D structure (AlphaFold-style) - Φ_seq(x) + Φ_struct(y) + Φ_align(seq, struct) 2. **Multi-Omics**: DNA + RNA + Protein + Methylation - 4-modality fusion with 6 alignment terms 3. **Pathway Analysis**: Function + Expression - Graph + vector alignment for active pathway detection -/ -- ═══════════════════════════════════════════════════════════════════════════ -- §7 Verification Examples -- ═══════════════════════════════════════════════════════════════════════════ #eval let seqData := { modality := Modality.sequence, data := [1.0, 0.0, 1.0, 0.0], shape := [4], metadata := "ATCG" : ModalityData } let structData := { modality := Modality.structure, data := [0.0, 1.0, 0.0, 1.0], shape := [4], metadata := "folded" : ModalityData } let params := ModalityFieldParams.sequenceStructureFusion let align := [(0, 1, { kappa := 0.1, delta := 0.5, weight := 1.0, wf_kappa_nonneg := by norm_num, wf_delta_pos := by norm_num, wf_weight_pos := by norm_num } : AlignmentParams)] crossModalField [seqData, structData] params align -- Expected: Individual sums + alignment (negative if dissimilar) #eval compressMultiModal [ { modality := Modality.sequence, data := [1.0, 2.0, 3.0], shape := [3], metadata := "test" } , { modality := Modality.expression, data := [1.0, 2.0, 3.0], shape := [3], metadata := "test" } ] ModalityFieldParams.multiOmicsFusion [(0, 1, { kappa := 0.1, delta := 0.1, weight := 1.0, wf_kappa_nonneg := by norm_num, wf_delta_pos := by norm_num, wf_weight_pos := by norm_num })] -- Expected: High compression ratio (similar data) -- ═══════════════════════════════════════════════════════════════════════════ -- §8 Future Work -- ═══════════════════════════════════════════════════════════════════════════ /-! ## Research Directions ### Immediate (This Week) - [ ] Connect to GenomicCompression for sequence parameters - [ ] Implement Python shim for modality data loading - [ ] Test on AlphaFold structures + sequences ### Short-term (Next 2 Weeks) - [ ] Multi-omics fusion: ENCODE + GTEx data - [ ] Prove crossModalAtLeastBestSingle theorem - [ ] Benchmark vs single-modal baselines ### Medium-term (Next Month) - [ ] Full 5-modality fusion (sequence + structure + function + expression + epigenetic) - [ ] Application: Cancer subtype classification - [ ] Paper: "Unified Field Theory for Multi-Omics Integration" ## References - MIRROR (2503.00374): Multi-modal pathological learning - AlphaFold: Structure prediction from sequence - ENCODE: Encyclopedia of DNA Elements (multi-modal data) -/ -- TODO(lean-port): -- 1. Complete alignmentHelpsWhenCoherent proof -- 2. Complete crossModalAtLeastBestSingle proof -- 3. Add projection functions (proj_i: modality → shared latent) -- 4. Connect to BettiSwoosh for topological alignment -- 5. Implement Python data loaders (h5ad, FASTA, PDB) end Semantics.CrossModalCompression