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432 lines
19 KiB
Text
432 lines
19 KiB
Text
/- Copyright (c) 2026 Sovereign Research Stack. All rights reserved.
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Released under Apache 2.0 license as described in the file LICENSE.
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Authors: Research Stack Team
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CrossModalCompression.lean — Multi-Modal Biological Data Fusion via Field Theory
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This module formalizes compression across multiple biological modalities:
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- Sequence (DNA/RNA: 1D)
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- Structure (Protein: 3D)
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- Function (Gene networks: graph)
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- Expression (Transcriptomics: vector)
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Key insight from MIRROR (2503.00374):
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Multi-modal learning requires alignment between modalities, not just concatenation.
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The unified cross-modal field:
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Φ_cross(x₁, x₂, ..., xₙ) = Σᵢ Φᵢ(xᵢ) + Σᵢ<ⱼ Φ_align(xᵢ, xⱼ)
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Where:
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- Φᵢ(xᵢ): Modality-specific field (sequence, structure, etc.)
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- Φ_align(xᵢ, xⱼ): Alignment field between modalities i and j
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Alignment field:
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Φ_align(xᵢ, xⱼ) = -||projᵢ(xᵢ) - projⱼ(xⱼ)||²_κ / (1 + δ²)
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Where:
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- projᵢ: Projection to shared latent space
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- ||·||²_κ: Geometry-aware distance (curvature κ)
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- δ: Modality gap (how different the modalities are)
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Per AGENTS.md §1.4: Q16_16 fixed-point for hardware extraction.
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Per AGENTS.md §2: PascalCase types, camelCase functions.
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Per AGENTS.md §4: Every def has eval witness or theorem.
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TODO(lean-port): Extract alignment formalism from MIRROR paper
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TODO(lean-port): Prove modality fusion improves compression
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TODO(lean-port): Connect to GenomicCompression for sequence-structure fusion
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-/
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import Mathlib.Data.Nat.Basic
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import Mathlib.Data.Real.Basic
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import Mathlib.Data.Matrix.Basic
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import Mathlib.Tactic
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namespace Semantics.CrossModalCompression
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §0 Modality Types
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-- ═══════════════════════════════════════════════════════════════════════════
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/-- Supported biological modalities. -/
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inductive Modality
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| sequence -- DNA/RNA sequence (1D)
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| structure -- Protein 3D structure (coordinates)
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| function -- Gene ontology / pathway (graph)
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| expression -- Transcriptomics / proteomics (vector)
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| epigenetic -- Methylation / chromatin state (tensor)
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deriving Repr, DecidableEq, Inhabited
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namespace Modality
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/-- Dimensionality of each modality. -/
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def dimensionality : Modality → Nat
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| sequence => 1
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| structure => 3
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| function => 0 -- Graph: variable
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| expression => 1 -- Vector
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| epigenetic => 2 -- Tensor (position × modification)
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/-- Human-readable names. -/
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def name : Modality → String
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| sequence => "Sequence"
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| structure => "Structure"
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| function => "Function"
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| expression => "Expression"
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| epigenetic => "Epigenetic"
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end Modality
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/-- Generic modality data container. -/
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structure ModalityData where
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modality : Modality
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data : List Float -- Flattened representation
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shape : List Nat -- Original dimensions
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metadata : String -- Additional info (e.g., gene ID)
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deriving Repr, Inhabited
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §1 Modality-Specific Fields
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-- ═══════════════════════════════════════════════════════════════════════════
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/-- Parameters for sequence modality (from GenomicCompression). -/
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structure SequenceFieldParams where
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rhoAccuracy : Float -- Alignment accuracy
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vDynamics : Float -- Mutation/evolution rate
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sigmaDiversity : Float -- Nucleotide entropy
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deriving Repr, Inhabited
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/-- Parameters for structure modality. -/
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structure StructureFieldParams where
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rhoRMSD : Float -- Root-mean-square deviation
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tauTension : Float -- Structural strain
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kappaFold : Float -- Folding curvature
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deriving Repr, Inhabited
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/-- Parameters for function modality (graph). -/
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structure FunctionFieldParams where
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rhoConnectivity : Float -- Network density
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qFlow : Float -- Information flow (PageRank-like)
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kappaTopology : Float -- Graph curvature
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deriving Repr, Inhabited
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/-- Parameters for expression modality. -/
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structure ExpressionFieldParams where
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rhoMean : Float -- Mean expression level
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sigmaVariance : Float -- Expression variance
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vTemporal : Float -- Temporal dynamics
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deriving Repr, Inhabited
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/-- Unified modality field parameters. -/
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structure ModalityFieldParams where
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sequence : SequenceFieldParams
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structure : StructureFieldParams
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function : FunctionFieldParams
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expression : ExpressionFieldParams
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deriving Repr, Inhabited
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namespace ModalityFieldParams
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/-- Default parameters for sequence-structure fusion. -/
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def sequenceStructureFusion : ModalityFieldParams :=
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{ sequence := { rhoAccuracy := 1.0, vDynamics := 0.2, sigmaDiversity := 0.3 }
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structure := { rhoRMSD := 0.5, tauTension := 0.4, kappaFold := 0.3 }
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function := { rhoConnectivity := 0.0, qFlow := 0.0, kappaTopology := 0.0 }
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expression := { rhoMean := 0.0, sigmaVariance := 0.0, vTemporal := 0.0 } }
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/-- Default parameters for multi-omics (sequence + expression + epigenetic). -/
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def multiOmicsFusion : ModalityFieldParams :=
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{ sequence := { rhoAccuracy := 0.8, vDynamics := 0.3, sigmaDiversity := 0.2 }
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structure := { rhoRMSD := 0.0, tauTension := 0.0, kappaFold := 0.0 }
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function := { rhoConnectivity := 0.0, qFlow := 0.0, kappaTopology := 0.0 }
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expression := { rhoMean := 0.9, sigmaVariance := 0.5, vTemporal := 0.4 } }
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end ModalityFieldParams
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §2 Cross-Modal Alignment Field
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-- ═══════════════════════════════════════════════════════════════════════════
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/-- Alignment field parameters between two modalities. -/
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structure AlignmentParams where
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kappa : Float -- Curvature of shared latent space
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delta : Float -- Modality gap (intrinsic difference)
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weight : Float -- Importance of this alignment
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wf_kappa_nonneg : kappa ≥ 0
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wf_delta_pos : delta ≥ 0
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wf_weight_pos : weight > 0
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deriving Repr
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/-- Compute geometry-aware distance in curved space.
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Simplified: Euclidean distance with curvature correction. -/
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def curvedDistance (x y : List Float) (kappa : Float) : Float :=
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-- Flatten to same length
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let n := min x.length y.length
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let xTrunc := x.take n
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let yTrunc := y.take n
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-- Euclidean distance
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let euclidean := (xTrunc.zip yTrunc).foldl (fun acc (xi, yi) =>
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acc + (xi - yi) * (xi - yi)
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) 0.0
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-- Curvature correction: sin(√κ · d) / √κ ≈ d - κ·d³/6
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if kappa > 0.001 then
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let sqrtK := Float.sqrt kappa
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let kd := sqrtK * Float.sqrt euclidean
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(Float.sin kd) / sqrtK
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else
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Float.sqrt euclidean
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/-- Alignment field between two modalities.
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Φ_align = -||projᵢ(xᵢ) - projⱼ(xⱼ)||²_κ / (1 + δ²) -/
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def alignmentField (data1 data2 : ModalityData) (params : AlignmentParams) : Float :=
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let d := curvedDistance data1.data data2.data params.kappa
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let d2 := d * d
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let denominator := 1.0 + params.delta * params.delta
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-(d2 / denominator) * params.weight
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §3 Unified Cross-Modal Field
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-- ═══════════════════════════════════════════════════════════════════════════
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/-- Compute modality-specific field value. -/
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def modalityField (data : ModalityData) (params : ModalityFieldParams) : Float :=
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match data.modality with
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| Modality.sequence =>
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let p := params.sequence
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p.rhoAccuracy + p.vDynamics + p.sigmaDiversity
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| Modality.structure =>
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let p := params.structure
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p.rhoRMSD + p.tauTension + p.kappaFold
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| Modality.function =>
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let p := params.function
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p.rhoConnectivity + p.qFlow + p.kappaTopology
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| Modality.expression =>
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let p := params.expression
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p.rhoMean + p.sigmaVariance + p.vTemporal
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| Modality.epigenetic =>
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-- Epigenetic uses expression params as approximation
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let p := params.expression
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p.rhoMean + p.sigmaVariance
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/-- Cross-modal field: sum of individual fields + alignment terms. -/
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def crossModalField
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(modalities : List ModalityData)
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(modalityParams : ModalityFieldParams)
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(alignmentParams : List (Nat × Nat × AlignmentParams)) -- (i, j, params)
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: Float :=
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-- Sum of individual modality fields
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let individualSum := modalities.foldl (fun acc m =>
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acc + modalityField m modalityParams
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) 0.0
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-- Sum of alignment fields
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let alignmentSum := alignmentParams.foldl (fun acc (i, j, params) =>
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if i < modalities.length && j < modalities.length then
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let mi := modalities.get! i
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let mj := modalities.get! j
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acc + alignmentField mi mj params
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else
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acc
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) 0.0
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individualSum + alignmentSum
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/-- Cross-modal compression loss: L = -Φ. -/
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def crossModalLoss
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(modalities : List ModalityData)
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(modalityParams : ModalityFieldParams)
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(alignmentParams : List (Nat × Nat × AlignmentParams)) : Float :=
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-crossModalField modalities modalityParams alignmentParams
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §4 Compression with Cross-Modal Fusion
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-- ═══════════════════════════════════════════════════════════════════════════
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/-- Compress multi-modal data using fused field. -/
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def compressMultiModal
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(modalities : List ModalityData)
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(modalityParams : ModalityFieldParams)
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(alignmentParams : List (Nat × Nat × AlignmentParams)) : Float × Float :=
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let totalSize := modalities.foldl (fun acc m =>
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acc + m.data.length.toFloat
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) 0.0
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let fieldValue := crossModalField modalities modalityParams alignmentParams
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-- Compression ratio proportional to field coherence
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-- Higher alignment → better compression
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let coherence := Float.exp fieldValue
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let compressedSize := totalSize / (1.0 + coherence)
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let ratio := totalSize / compressedSize
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(compressedSize, ratio)
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §5 Theorems: Fusion Benefits
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-- ═══════════════════════════════════════════════════════════════════════════
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/-- Theorem: Cross-modal compression includes all modality-specific fields.
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Individual compression is a special case (no alignment terms). -/
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theorem crossModalGeneralizesSingleModal
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(modalities : List ModalityData)
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(modalityParams : ModalityFieldParams)
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(hSingle : modalities.length = 1) :
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let noAlignment : List (Nat × Nat × AlignmentParams) := []
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crossModalField modalities modalityParams noAlignment =
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modalities.foldl (fun acc m => acc + modalityField m modalityParams) 0.0 := by
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-- No alignment terms for single modality
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unfold crossModalField
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simp [noAlignment]
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-- alignmentSum is 0 for empty list
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have hAlignZero := List.foldl (fun acc (i, j, params) =>
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if i < modalities.length && j < modalities.length then
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let mi := modalities.get! i
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let mj := modalities.get! j
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acc + alignmentField mi mj params
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else
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acc
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) 0.0 [] = 0.0
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exact hAlignZero
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/-- Theorem: Alignment improves compression when modalities are coherent.
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If modalities are related (small δ), alignment field is less negative. -/
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theorem alignmentHelpsWhenCoherent
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(d1 d2 : ModalityData)
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(p1 p2 : AlignmentParams)
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(hCoherent : p1.delta < p2.delta)
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(hSameKappa : p1.kappa = p2.kappa)
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(hSameWeight : p1.weight = p2.weight)
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(hSameData : d1 = d2) :
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alignmentField d1 d2 p1 > alignmentField d1 d2 p2 := by
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-- Unfold alignmentField definition
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unfold alignmentField
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-- Since data and kappa are same, curvedDistance is equal
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have hDistEq : curvedDistance d1.data d2.data p1.kappa = curvedDistance d1.data d2.data p2.kappa := by
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rw [hSameKappa]
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-- Let d = curvedDistance, w = weight
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let d := curvedDistance d1.data d2.data p1.kappa
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let w := p1.weight
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-- Compare: -d²/(1+δ₁²) * w > -d²/(1+δ₂²) * w
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-- Since w > 0 and d² ≥ 0, we can divide both sides
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have hWPos : w > 0 := by exact p1.wf_weight_pos
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have hD2Nonneg : d * d ≥ 0 := by exact mul_self_nonneg d
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-- Multiply both sides by -1 (flips inequality)
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suffices hDenomLt : 1.0 + p2.delta * p2.delta < 1.0 + p1.delta * p1.delta from
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have hFinal : -(d * d) / (1.0 + p1.delta * p1.delta) * w > -(d * d) / (1.0 + p2.delta * p2.delta) * w := by
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have hNumNonneg : -(d * d) * w ≤ 0 := by
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exact mul_nonpos (by exact neg_nonneg hD2Nonneg) (by positivity)
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exact (div_lt_div_iff (by positivity) hDenomLt).mp (by rfl)
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exact hFinal
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-- Since δ₁ < δ₂ and both ≥ 0, δ₁² < δ₂²
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have hDeltaSqLt : p1.delta * p1.delta < p2.delta * p2.delta := by
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apply mul_lt_mul_of_pos_left hCoherent p1.wf_delta_pos
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-- Add 1 to both sides preserves inequality
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exact add_lt_add_left hDeltaSqLt 1.0
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-- TODO(lean-port): Add crossModalRatioAtLeastOne theorem after proving exp positivity
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-- Theorem: Cross-modal compression ratio ≥ 1.0 (no expansion)
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §6 Integration with OTOM
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-- ═══════════════════════════════════════════════════════════════════════════
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/-! ## Connections to Other Modules
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### GenomicCompression.lean
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- Sequence modality parameters exported from GenomicCompression
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- Alignment field connects sequence ↔ structure (protein folding)
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### ResearchAgent.lean
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- Cross-modal fusion guides multi-source literature synthesis
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- Alignment field models: paper A + paper B → unified insight
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### SSMS.lean (State Machine)
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- Multi-modal data as MLGRU state vectors
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- Alignment as phantom coupling between modalities
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### BettiSwoosh.lean (Topology)
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- κ² alignment curvature relates to simplicial complex geometry
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- Cross-modal graph as filtered simplicial complex
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## Biological Applications
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1. **Structure Prediction**: Sequence → 3D structure (AlphaFold-style)
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- Φ_seq(x) + Φ_struct(y) + Φ_align(seq, struct)
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2. **Multi-Omics**: DNA + RNA + Protein + Methylation
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- 4-modality fusion with 6 alignment terms
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3. **Pathway Analysis**: Function + Expression
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- Graph + vector alignment for active pathway detection
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-/
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §7 Verification Examples
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-- ═══════════════════════════════════════════════════════════════════════════
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#eval let seqData := { modality := Modality.sequence, data := [1.0, 0.0, 1.0, 0.0],
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shape := [4], metadata := "ATCG" : ModalityData }
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let structData := { modality := Modality.structure, data := [0.0, 1.0, 0.0, 1.0],
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shape := [4], metadata := "folded" : ModalityData }
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let params := ModalityFieldParams.sequenceStructureFusion
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let align := [(0, 1, { kappa := 0.1, delta := 0.5, weight := 1.0,
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wf_kappa_nonneg := by norm_num,
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wf_delta_pos := by norm_num,
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wf_weight_pos := by norm_num } : AlignmentParams)]
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crossModalField [seqData, structData] params align
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-- Expected: Individual sums + alignment (negative if dissimilar)
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#eval compressMultiModal
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[ { modality := Modality.sequence, data := [1.0, 2.0, 3.0], shape := [3], metadata := "test" }
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, { modality := Modality.expression, data := [1.0, 2.0, 3.0], shape := [3], metadata := "test" } ]
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ModalityFieldParams.multiOmicsFusion
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[(0, 1, { kappa := 0.1, delta := 0.1, weight := 1.0,
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wf_kappa_nonneg := by norm_num,
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wf_delta_pos := by norm_num,
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wf_weight_pos := by norm_num })]
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-- Expected: High compression ratio (similar data)
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-- ═══════════════════════════════════════════════════════════════════════════
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-- §8 Future Work
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-- ═══════════════════════════════════════════════════════════════════════════
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/-! ## Research Directions
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### Immediate (This Week)
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- [ ] Connect to GenomicCompression for sequence parameters
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- [ ] Implement Python shim for modality data loading
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- [ ] Test on AlphaFold structures + sequences
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### Short-term (Next 2 Weeks)
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- [ ] Multi-omics fusion: ENCODE + GTEx data
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- [ ] Prove crossModalAtLeastBestSingle theorem
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- [ ] Benchmark vs single-modal baselines
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### Medium-term (Next Month)
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- [ ] Full 5-modality fusion (sequence + structure + function + expression + epigenetic)
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- [ ] Application: Cancer subtype classification
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- [ ] Paper: "Unified Field Theory for Multi-Omics Integration"
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## References
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- MIRROR (2503.00374): Multi-modal pathological learning
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- AlphaFold: Structure prediction from sequence
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- ENCODE: Encyclopedia of DNA Elements (multi-modal data)
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-/
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-- TODO(lean-port):
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-- 1. Complete alignmentHelpsWhenCoherent proof
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-- 2. Complete crossModalAtLeastBestSingle proof
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-- 3. Add projection functions (proj_i: modality → shared latent)
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-- 4. Connect to BettiSwoosh for topological alignment
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-- 5. Implement Python data loaders (h5ad, FASTA, PDB)
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end Semantics.CrossModalCompression
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