mirror of
https://github.com/allaunthefox/Research-Stack.git
synced 2026-07-31 03:05:21 +00:00
91 lines
3.9 KiB
Python
91 lines
3.9 KiB
Python
#!/usr/bin/env python3
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"""Ingest MS myelin glucose signaling article into Research Stack database."""
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import json, time, hashlib
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from pathlib import Path
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RESEARCH_STACK = Path("/home/allaun/Documents/Research Stack")
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ARTICLE = {
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"id": "ms-myelin-glucose-2026-05-04",
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"source": "https://multiplesclerosisnewstoday.com/news-posts/2026/05/04/brain-sugar-levels-act-signal-myelin-growth-study-finds/",
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"title": "Brain sugar levels act as signal for myelin growth, study finds",
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"date": "2026-05-04",
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"publication": "Multiple Sclerosis News Today",
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"summary": "Glucose levels in the brain regulate oligodendrocyte progenitor cell (OPC) fate — high glucose drives OPC proliferation via histone acetylation, low glucose triggers maturation into myelin-producing oligodendrocytes. Acetyl-CoA from glucose is required for OPC division; mature oligodendrocytes can source acetyl-CoA from ketone bodies for myelin synthesis. ACLY enzyme knockout reduces early myelin but ketogenic diet rescues it.",
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"key_findings": [
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"OPC activity correlates with local brain glucose levels",
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"High glucose → acetyl-CoA → histone acetylation → OPC proliferation",
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"Low glucose → OPC maturation into myelin-producing oligodendrocytes",
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"ACLY enzyme required for glucose-to-acetyl-CoA conversion in OPCs",
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"Mature oligodendrocytes use ketone bodies as alternative acetyl-CoA source",
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"Ketogenic diet rescues myelin production in ACLY-deficient mice",
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"Same cell lineage interprets different metabolic signals at distinct stages"
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],
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"relevance_to_research_stack": {
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"topics": [
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"metabolic_epigenetic_switch",
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"myelin_repair_mechanism",
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"glucose_signaling_pathway",
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"oligodendrocyte_differentiation",
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"ketogenic_metabolic_intervention",
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"histone_acetylation_gene_regulation"
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],
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"connections": [
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"N-Dimensional Gene Hypothesis: glucose gradient as spatial morphogen signal",
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"PIST biological polymorphic shifter: metabolic state → cell fate switch",
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"Topological state machine: glucose level as continuous state variable",
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"FAMM delay lines: metabolic latency in cell fate decisions",
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"Waveprobe manifolds: glucose gradient as scalar field on brain manifold"
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]
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},
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"metadata": {
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"ingested_at": time.time(),
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"content_hash": hashlib.sha256(
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"glucose myelin OPC oligodendrocyte acetyl-CoA ACLY ketogenic histone acetylation".encode()
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).hexdigest()[:16],
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"tags": ["neuroscience", "metabolism", "myelin", "multiple-sclerosis", "epigenetics", "glucose-signaling"]
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}
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}
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def ingest():
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# Save to germane research data
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germane_dir = RESEARCH_STACK / "shared-data/data/germane/research"
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germane_dir.mkdir(parents=True, exist_ok=True)
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out_path = germane_dir / "ms_myelin_glucose_signaling_2026-05-04.json"
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with open(out_path, 'w') as f:
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json.dump(ARTICLE, f, indent=2)
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print(f"✓ Ingested: {out_path}")
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# Append to research index
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index_path = germane_dir / "research_ingestion_index.json"
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index = []
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if index_path.exists():
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with open(index_path) as f:
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index = json.load(f)
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index.append({
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"id": ARTICLE["id"],
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"title": ARTICLE["title"],
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"date": ARTICLE["date"],
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"source": ARTICLE["source"],
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"ingested_at": ARTICLE["metadata"]["ingested_at"],
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"tags": ARTICLE["metadata"]["tags"],
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})
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with open(index_path, 'w') as f:
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json.dump(index, f, indent=2)
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print(f"✓ Index updated: {index_path} ({len(index)} entries)")
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# Print connections
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print(f"\nResearch Stack connections:")
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for conn in ARTICLE["relevance_to_research_stack"]["connections"]:
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print(f" → {conn}")
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if __name__ == "__main__":
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ingest()
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